mGLU Receptors by Richard Teke Ngomba Giuseppe Di Giovanni Giuseppe Battaglia & Ferdinando Nicoletti

Author:Richard Teke Ngomba, Giuseppe Di Giovanni, Giuseppe Battaglia & Ferdinando Nicoletti
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

Fig. 7.7Structural dynamics of the mGluRs (Figure with permission from Rondard and Pin 2015). (a) Based on smFRET experiments, we have shown that ECD dimers oscillate between the resting and active states, whether unbound or bound to an agonist or an antagonist (Olofsson et al. 2014). (b) Model of the 7TM of the mGlu2 receptor in the resting and active states, illustrating the large rearrangement that occurs at the 7TM dimer interface during receptor activation (Xue et al. 2015). The position of cysteine residues introduced in TM4 and TM5 or in TM6 are indicated in orange and red, respectively

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